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N-Acetyl-D-lactosamine  

2010-11-10 12:13:09|  分类: 糖化学-复杂碳水 |  标签: |举报 |字号 订阅

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N-Acetyl-D-lactosamine           10mg  ,25mg ,100mg

N-Acetyl-D-lactosamine is a disaccharide, consisting of galactose and N-acetylglucose units, which often appears as a structural element in glycoconjugates of biological significance,1 for example, it is a core unit of carbohydrates isolated from human milk.2
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CAS No:    32181-59-2
Synonyms:LacNAc
Galactopyranosyl-b-1,4-N-acetyl-D-glucosamine
2-Acetamido-2-deoxy-D-lactose
Chemical Formula:C14H25NO11
Molecular Weight:383.35

Lectins are sugar-binding proteins with high specificity for their sugar moieties, and are typically involved in biological recognition processes involving cells and proteins. N-Acetyl-D-lactosamine and derivatives are widely used in the characterisation and investigation of the roles and utility of lectins from diverse sources.

For example, lectins from Arisaema intermedium, A. wallichianum, A. flavum and A. helleborifolium have specificity for N-Acetyl-D-lactosamine.3,4,5 In the case of A. helleborifolium lectin (AHL), it has been shown that this has an in vitro anti-proliferative effect on several tumour cell lines, perhaps due to the ability to recognise carbohydrate profiles containing N-acetyl-D-lactosamine components on these cell lines. Additionally, in the same study, AHL was shown to have anti-insect activity.3

N-Acetyl-D-lactosamine is an essential component of the tetrasaccharide Sialyl LewisX, Figure 1, (also known as known as Sialyl LeX and SLeX), which is located on the terminus of glycolipids on the surface of leukocytes (white blood cells) such as neutrophils.6 Sialyl LewisX plays an important role in inflammatory processes, mediating the adhesion of leukocytes to sites of injury via recognition of the lectin by E-selectin, an adhesion molecule on endothelial cells. High expression of Sialyl LewisX has been observed in certain tumour cells, such as those in breast and colorectal cancer.7,8
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