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Jackson二抗授权|蛋白|细胞因子

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R&D Systems公司细胞生物学,提供优质的蛋白质,抗体,ELISA试剂盒,实验室试剂,细胞因子.包括Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics. Jackson二抗中国授权代理

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MAPK 系列研究及抑制剂  

2010-11-12 11:46:56|  分类: 生物化学试剂 |  标签: |举报 |字号 订阅

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The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK. Upon activation, MAPK can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, membrane and cytoplasmic substrates, and other protein kinases. Three major groups of MAPK cascades have been determined: ERK1/ERK2, JNK/SAPK and p38 MAPK.
MAPK Signaling Target FilesMAPK 系列研究及抑制剂 - Solomon - 标准品生化试剂毒素酶试剂盒
MYC         Raf Kinase
AP-1         MAPK            MEK
详细产品信息如下:
MYC
TS2360      
Anti-N-Myc (Clone NMYC-1)    100ug
Antibody recognizing N-Myc ,
Recognizes Human and Mouse MYC. 
Not yet tested in other species.
Host:Mouse              Clonality:monoclonal
Isotype:IgG2a           Purification:Protein A
AP-1  Inhibitors            
TS1989     c-JUN peptide          1mg
分子量:2743.55
分子式:C121H210N36O34S
Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.
    JNK/c-Jun interaction inhibitor
TS2476      SR 11302                 10mg
分子量:376.54
分子式:C26H32O2
Solubility:Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:>98 %
CAS No:[160162-42-5]
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
    Inhibitor of AP-1 transcription factor; antitumor agent
电话:13788991907   E-mail:电话@163.com提供
Raf Kinase   Inhibitors   
TS1381     GW 5074              10mg ,50mg 
Chemical Name: 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
分子量: 520.94           分子式C15H8Br2INO2
Solubility:Soluble to 1 mM in ethanol and to 100 mM in DMSO
Purity:>98 %
CAS No:[220904-83-6]
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
   
TS3185       L-779,450           10mg ,50mg 
Chemical Name: 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol
分子量:347.8               分子式:C20H14ClN3O
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>99 %        CAS No:[303727-31-3]
Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.
TS1321     ZM 336372
    Potent, selective c-Raf inhibito
MAPK
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions. Six groups of MAPK have so far been identified:
   1. Extracellular signal-regulated kinases (ERK1, ERK2).   2. c-Jun N-terminal kinases (JNKs)   3. p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14)
   4. ERK5 (MAPK7)   5. ERK3 (MAPK6) and ERK4 (MAPK4)   6. ERK7/8 (MAPK15)

p38 MAPK :
TS2999      RWJ 67657
    Potent, selective p38α and p38β inhibitor
TS1202     SB 203580
    Selective inhibitor of p38 MAPK
抑制剂:
TS2186       CMPD-1
    Non-ATP-competitive p38α inhibitor
TS2908     EO 1428
    Selective inhibitor of p38α and p38β2
TS2657     JX 401
    Potent, reversible p38α inhibitor
TS2999     RWJ 67657
    Potent, selective p38α and p38β inhibitor
TS1264     SB 202190
    Potent, selective inhibitor of p38 MAPK
TS1202     SB 203580
    Selective inhibitor of p38 MAPK
TS1402     SB 203580 hydrochloride
    Selective inhibitor of p38 MAPK; water-soluble
TS1962     SB 239063
    Potent, selective p38 MAPK inhibitor; orally active
TS2938     SD 169
    Selective, orally active p38α inhibitor
TS2008     SKF 86002 dihydrochloride
    p38 MAPK inhibitor; anti-inflammatory agent
TS3639     SX 011new product
    p38 MAPK inhibitor
TS3916     VX 702
    Orally active p38α and p38β inhibitor
ERK       
电话:13788991907   E-mail:电话@163.com提供
TS3706       FR 180204
    Selective ERK inhibitor
 
JNK/c-Jun
TS1496       SP 600125
    Novel and selective JNK inhibitor
Inhibitors
TS2651     AEG 3482
    Inhibitor of JNK signaling
TS3314     BI 78D3
    Selective, competitive JNK inhibitor
TS1989     c-JUN peptide
    Peptide inhibitor of JNK/c-Jun interaction
TS1565     JIP-1 (153-163)
    JNK-selective inhibitor peptide
TS1496     SP 600125
    Novel and selective JNK inhibitor
TS3607     SU 3327
    Selective JNK inhibitor
TS2827     TCS JNK 5a
    Selective inhibitor of JNK2 and JNK3
电话:13788991907   E-mail:电话@163.com提供
MEK   抑制剂
TS1777     Arctigenin              10mg  , 50mg  
Alternative Name: (-)-Arctigenin
Chemical Name: (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
分子量:372.42          分子式:C21H24O6
Solubility:Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:>99 %            CAS No:[7770-78-7]
Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.
    Potent MKK1 inhibitor. Also inhibits IκBα phosphorylation

TS2605     PD 198306
    Selective inhibitor of MEK1/2
TS1213     PD 98059
    Specific inhibitor of MEK
TS1969     SL 327
    Selective inhibitor of MEK1 and MEK2; brain penetrant
TS1868     U0124
    Inactive analog of U0126
TS1144     U0126
    Potent, selective inhibitor of MEK1 and 2
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