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Vortioxetine 抗精神抑郁症研究,科研分析实验室专用  

2013-11-12 21:01:11|  分类: 分析试剂 |  标签: |举报 |字号 订阅

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上海惠诚生物提供 Vortioxetine科研实验室用试剂,>98%
Vortioxetine    5mg /1696元,10mg/ 2660元 , 25mg,100mg  请咨询 021-60498804
vortioxetine通过抑制5 - 羟色胺转运体和5 HT3A,7受体在大脑中的5 - 羟色胺水平调制
Vortioxetine is an antidepressant and anxiolytic. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter and 5-HT3A,7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.
Vortioxetine 抗精神抑郁症研究 - Solomon - 标准品生化试剂毒素酶试剂盒当前您的位置:首页>>分析化学>>抗精神抑郁症研究>>Vortioxetine
Vortioxetine 抗精神抑郁症研究 - Solomon - 标准品生化试剂毒素酶试剂盒
Cat. Number
TKV5870
Chemical Name
CAS Number
508233-74-7
Category
药物分析实验室科研用试剂
Mol. Formula
C18H22N2S
Mol. Weight
298.45
Qty 1
10mg
Qty 2
100mg
Application Notes
>98%
Storage condition
+4°C
References

上海惠诚生物提供 Vortioxetine科研实验室用试剂,>98% 
Vortioxetine    5mg /1696元,10mg/ 2660元 , 25mg,100mg  请联系我们
通过抑制5 - 羟色胺转运体和5 HT3A,7受体在大脑中的5 - 羟色胺水平调制
Vortioxetine is an antidepressant and anxiolytic. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter and 5-HT3A,7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.
C18H22N2S = 298.45
文献相关参考:
du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504.

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346.

Bang-Andersen B, Ruhland T, J?rgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.

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