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Sialic Acid  

2014-08-21 13:19:03|  分类: 默认分类 |  标签: |举报 |字号 订阅

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Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a nine-carbon monosaccharide. It is also the name for the most common member of this group, N-acetylneuraminic acid (Neu5Ac or NANA)

Sialic acids are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. The amino group bears either an acetyl or a glycolyl group. Sialic acid is a synthetic product and is the pure N-acetyl compound. Sialic acid is also found widely in endothelial tissue and elsewhere; conjugated to a range of glycoproteins and glycolipids. It is considered to be the functional part of sialyllactose found in milk and colostrum.
 
Despite its role of acting as "decoy" for invading pathogens, Neu5Ac is becoming known as an agent necessary for mediating ganglioside distribution and structures in the brain.
 
Along with involvement in preventing infections (mucus associated with mucous membranes - mouth, nose, GI, respiratory tract), Neu5Ac acts as a receptor for influenza viruses to allow attachment to mucous cells (an early step in contracting the flu).

Use of Chemical

Sialic acid is used in the production of several neuraminidase inhibitors, glycolipids and other synthetically derived bio-active products.
 
Sialic acid could find a valuable role in dietary supplements as a glyconutrient.

Specifications

  • CAS Number: 131-48-6
  • Molecular Weight: 309.27
  • Solubility: Water soluble
  • Packaging: Sialic acid is sold as a white to off-white powder.  suitable for GMP audits on customer request. Packaging to customer specifications.

Synonyms

N-Acetylneuraminic acid
Neu5Ac
NANA

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