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Jackson二抗授权|蛋白|细胞因子

西宝生物科研试剂团队服务糖,寡糖,多糖及检测服务和原料供应。Jackson二抗

 
 
 

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R&D Systems公司细胞生物学,提供优质的蛋白质,抗体,ELISA试剂盒,实验室试剂,细胞因子.包括Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics. Jackson二抗中国授权代理

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γ分泌酶 γ-Secretase Inhibitor  

2014-09-10 13:49:36|  分类: 酶,蛋白质,肽 |  标签: |举报 |字号 订阅

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(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu  (5 mg /2195元 ,10mg /2996元)
DAPT
(3,5-Difluorophenylacetyl)-L-2-Alanyl-L-Phenylglycine t-Butyl Ester
(M.W. 432.46) C23H26N2O4F2
Synthetic Product
Inhibitor for gamma-Secretase
H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, P. de Saint Andrieu, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholodenko, J.E. Knops, L.H. Latimer, M. Lee, Z. Liao, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. Dieckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W.-Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, B. Ni, J.S. Nissen, W.J. Porter, B.D. Potts, J.K. Reel, D. Stephenson, Y. Su, L.A. Shipley, C.A. Whitesitt, T. Yin, and J.E. Audia, J. Neurochem., 76, 173 (2001). (Original; Functional γ-Secretase Inhibitor in Brain)
A.Y. Kornilova, C. Das, and M.S. Wolfe, J. Biol. Chem., 278, 16470 (2003). (Comparison of in Cells and Cell-Free Activity)

Ac-Leu-Pro-N-Me-Phe-Phe-Asp-NH2    5mg /1920元
beta-Sheet Breaker Peptide iAbeta5p-A1
(M.W. 692.82) C36H48N6O8
A beta (1-42) Fibrillogenesis Inhibitor, iA beta5p-A1
C. Adessi, M.J. Frossard, C. Boissard, S. Fraga, S. Bieler, T. Ruckle, F. Vilbois, S.M. Robinson, M. Mutter, W.A. Banks, and C. Soto, J. Biol. Chem., 278, 13905, (2003).
上海惠诚生物为广大科研用户提供科学仪器,试剂耗材等专业科研产品服务。
代理产品品牌有:Nu-chek、LKT、AccuStandard、APSC、MPBio、Sigma-Aldrich、NIST,Reagecon、Megazyme,LGC、Ultra,日本和光(WAKO)、Shodex,Dr.E、PSS ,Matreya,CaroteNature瑞典Larodan产品,Chromadex等。提供美国药典USP 、欧洲药典标 EDQM、加拿大TRC标准物质等

TEL: 137888991907   E-mail:TEL NO @163.COM
Beta-Sheet Breaker Peptide iAbeta5 (5 mg /1920元)
Leu-Pro-Phe-Phe-Asp
Inhibitor of Amyloid Deposition
C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione, Nat. Med., 4, 822 (1998). (Original, Pharmacol.)

(Z-Leu-Leu-NHCH2)2CO (5 mg /1892元)
[(Z-LL)2 Ketone]
1,3-Bis[(Benzyloxycarbonyl-L-Leucyl-L-Leucyl)Amino]Acetone
(M.W. 809.00) C43H64N6O9
Synthetic Product
Inhibitor for Signal Peptide Peptidase
A. Weihofen, M.K. Lemberg, H.L. Ploegh, M. Bogyo, and B. Martoglio, J. Biol. Chem., 275, 30951 (2000). (Original)
A. Weihofen, K. Binns, M.K. Lemberg, K. Ashman, and B. Martoglio, Science, 296, 2215 (2002). (Signal Peptide Peptidase Inhibitor)
A. Weihofen, M.K. Lemberg, E. Friedmann, H. Rueeger, A. Schmitz, P. Paganetti, G. Rovelli, and B. Martoglio, J. Biol. Chem., 278, 16528 (2003). (Signal Peptide Peptidase Inhibitory Activity)

Ac-Asp-Asn-Leu-Asp-H (aldehyde) (5 mg vial)
[Ac-DNLD-CHO]
Acetyl-L-Aspartyl-L-Asparaginyl-L-Leucyl-L-Aspart-1-al
(M.W. 501.49) C20H31N5O10
Synthetic Product
Selective Inhibitor for Caspase-3 Designed by in silico Screening System
A. Yoshimori, R. Takasawa, and S. Tanuma, BMC Pharmacol., 4, 7 (2004).
A. Yoshimori, R. Takasawa, and S. Tanuma, Bio. Pharm. Bull., 27, 968 (2004).

Ac-Asp-Gln-Thr-Asp-H (aldehyde) (5 mg vial)
[Ac-DQTD-CHO]
Acetyl-L-Aspartyl-L-Glutaminyl-L-Threonyl-L-Aspart-1-al
(M.W. 503.46) C19H29N5O11
Synthetic Product
Inhibitor for Caspase-7/3
(Deduced from the Cleavage Site of Focal Adhesion Kinase and Gelsolin)
L.-P. Wen, J.A. Fahrni, S. Troie, J.-L. Guan, K. Orth, and G.D. Rosen, J. Biol. Chem., 272, 26056 (1997).
S. Kothakota, T. Azuma, C. Reinhard, A. Klippel, J. Tang, K. Chu, T.J. McGarry, M.W. Kirschner, K. Koths, D.J. Kwiatkowski, and L.T. Williams, Science, 278, 294 (1997).


Ac-Asp-Glu-Val-Asp-H (aldehyde) (5 mg/4520元)
[Ac-DEVD-CHO]  CAS:184179-08-6
Acetyl-L-Aspartyl-L-Glutamyl-L-Valyl-L-Aspart-1-al
(M.W. 502.47) C20H30N4O11 [184179-08-6]
Synthetic Product
Inhibitor for Caspase-3/7/8
D.W. Nicholson, A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, N.A. Munday, S.M. Raju, M.E. Smulson, T.-T. Yamin, V.L. Yu, and D.K. Miller, Nature, 376, 37 (1995).
M. Enari, R.V. Talanian, W.W. Wong, and S. Nagata, Nature, 380, 723 (1996).
N.A. Thornberry, T.A. Rano, E.P. Peterson, D.M. Rasper, T. Timkey, M. Garcia-Calvo, V.M. Houtzager, P.A. Nordstrom, S. Roy, J.P. Vaillancourt, K.T. Chapman, and D.W. Nicholson, J. Biol. Chem., 272, 17907 (1997).

Ac-Asp-Met-Gln-Asp-H (aldehyde) (5 mg /6996元)
[Ac-DMQD-CHO]   CAS:259199-63-8
Acetyl-L-Aspartyl-L-Methionyl-L-Glutaminyl-L-Aspart-1-al
(M.W. 533.55) C20H31N5O10S [259199-63-8]
Synthetic Product
Inhibitor for Caspase-3
A. Takahashi, H. Hirata, S. Yonehara, Y. Imai, K.-K. Lee, R.W. Moyer, P.C. Turner, P.W. Mesner, T. Okazaki, H. Sawai, S. Kishi, K. Yamamoto, M. Okuma, and M. Sasada, Oncogene, 14, 2741 (1997).
H. Hirata, A. Takahashi, S. Kobayashi, S. Yonehara, H. Sawai, T. Okazaki, K. Yamamoto, and M. Sasada, J. Exp. Med., 187, 587 (1998).

Ac-Ile-Glu-Thr-Asp-H (aldehyde) (5 mg /4596元)
[Ac-IETD-CHO]
Acetyl-L-Isoleucyl-L-Glutamyl-L-Threonyl-L-Aspart-1-al
(M.W. 502.52) C21H34N4O10 [191338-86-0]
Synthetic Product
Inhibitor for Caspase-8/6 and Granzyme B
(Deduced from the Cleavage Site of Procaspase-3)
Z. Han, E.A. Hendrickson, T. A. Bremner, and J.H. Wyche, J. Biol. Chem., 272, 13432 (1997).
M. Garcia-Calvo, E.P. Peterson, B. Leiting, R. Ruel, D.W. Nicholson, and N.A. Thornberry, J. Biol. Chem., 273, 32608 (1998).

Ac-Leu-Glu-His-Asp-H (aldehyde) (5 mg/5921元)
Ac-LEHD-CHO]
(Trifluoroacetate Form)
Acetyl-L-Leucyl-L-Glutamyl-L-Histidyl-L-Aspart-1-al
(M.W. 538.55) C23H34N6O9
Synthetic Product
Inhibitor for Caspase-9
N.A. Thornberry, T.A. Rano, E.P. Peterson, D.M. Rasper, T. Timkey, M. Garcia-Calvo, V.M. Houtzager, P.A. Nordstrom, S. Roy, J.P. Vaillancourt, K.T. Chapman, and D.W. Nicholson, J. Biol. Chem., 272, 17907 (1997).

Ac-Leu-Leu-Met-H
(aldehyde)(5 mg/921元)
ALLM
Acetyl-L-Leucyl-L-Leucyl-L-Methioninal
(M.W. 401.57) C19H35N3O4S
Inhibitor for Calpain II and Proteasome
T. Sasaki, M. Kishi, M. Saito, T. Tanaka, N. Higuchi, E. Kominami, N. Katunuma, and T. Murachi, J. Enzyme Inhib., 3, 195 (1990).

Ac-Leu-Leu-Nle-H (aldehyde)(5 mg/921元)
ALLN, MG 101
Acetyl-L-Leucyl-L-Leucyl-L-Norleucinal
(M.W. 383.54) C20H37N3O4
Inhibitor for Calpain I and Proteasome
T. Sasaki, M. Kishi, M. Saito, T. Tanaka, N. Higuchi, E. Kominami, N. Katunuma, and T. Murachi, J. Enzyme Inhib., 3, 195 (1990).

Ac-SIMP-1   (5 mg/1521元)
Ac-S-CH2-(R)-CH(CH2CH(CH3)2)-CO-Phe-Ala-NH2
(2R)-S-Acetyl-2-Mercaptomethyl-4-Methylpentanoyl-L-Phenylalanyl-L-Alanine Amide
(M.W. 421.56) C21H31N3O4S
(Protected precursor)
Collagenase Inhibitor
SIMP-1  (5 mg/1821元)
HS-CH2-(R)-CH(CH2CH(CH3)2)-CO-Phe-Ala-NH2
(2R)-2-Mercaptomethyl-4-Methypentanoyl-L-Phenylalanyl-L-Alanine Amide
(M.W. 379.52) C19H29N3O3S
(Free thiol form)
Collagenase Inhibitor
? Product produced under license from Research Corporation Technologies.

Ac-SIMP-2 (5 mg/1921元)
Ac-S-CH2-(R)-CH(CH2CH(CH3)2)-CO-Nal-Ala-NH2
(2R)-S-Acetyl-2-Mercaptomethyl-4-Methypentanoyl-L-beta-(2-Naphthyl)alanyl-L-Alanine Amide
(M.W. 471.62) C25H33N3O4S
(Protected precursor)
Collagenase Inhibitor
? Product produced under license from Research Corporation Technologies.

Actinonin
  25 mg/2281元 ,100mg /7620
3-[[1-[[2-(Hydroxymethyl)-1-Pyrolidinyl]-Carbonyl]-
2-Methylpropyl]-Carbamoyl]-Octanohydroxamic Acid
(M.W. 385.51) C19H35N3O5 [13434-13-4]
Synthetic Product
Inhibitor for Aminopeptidase M and Leucyl Aminopeptidase

Ac-Trp-Glu-His-Asp-H (aldehyde) (5 mg/4621元)
Ac-WEHD-CHO] (Trifluoroacetate Form)  CAS:189275-71-6
Acetyl-L-Tryptophyl-L-Glutamyl-L-Histidyl-L-Aspart-1-al
(M.W. 611.60) C28H33N7O9 [189275-71-6]
Synthetic Product
Inhibitor for Caspase-1
T.A. Rano, T. Timkey, E.P. Peterson, J. Rotonda, D.W. Nicholson, J.W. Becker, K.T. Chapman, and N.A. Thornberry, Chem. Biol., 4, 149 (1997).
M. Garcia-Calvo, E.P. Peterson, B. Leiting, R. Ruel, D.W. Nicholson, and N.A. Thornberry, J. Biol. Chem., 273, 32608 (1998).

Ac-Tyr-Val-Ala-Asp-CH2Cl (5 mg/4620元)
[Ac-YVAD-CMK]
Acetyl-L-Tyrosyl-L-Valyl-L-Alanyl-L-Aspart-1-ylChloromethane
(M.W. 540.99) C24H33N4O8Cl [178603-78-6]
Synthetic Product
Inhibitor for Caspases
Y.A. Lazebnik, S.H. Kaufmann, S. Desnoyers, G.G. Poirier, and W.C. Earnshaw, Nature, 371, 346 (1994).
M. Enari, H. Hug, and S. Nagata, Nature, 375, 78 (1995).
C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim, and L.M. Schwartz, Neuron, 15, 385 (1995).
E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Omura, and T. Momoi, Biochem. Biophys. Res. Commun., 224, 74 (1996).


Ac-Tyr-Val-Ala-Asp-CH2Cl (5 mg vial)
Ac-Tyr-Val-Ala-Asp-H (aldehyde) (5 mg vial)
Ac-Tyr-Val-Lys-Asp-H (aldehyde) (5 mg vial)
Ac-Val-Asp-Val-Ala-Asp-H (aldehyde) (5 mg vial)
Ac-Val-Glu-Ile-Asp-H (aldehyde) (5 mg vial)
Ala-Ala-Phe-CH2Cl (5 mg vial)
Amastatin
Amastatin (0.5 mg vial)
Antipain
Antipain (0.5 mg vial)
Aprotinin
Arphamenine A
Arphamenine A (0.5 mg vial)
Arphamenine B

E-64
E-64 (0.5 mg vial)
E-64-c (5 mg vial)
E-64-d (5 mg vial)
Ebelactone A
Ebelactone B
Elastatinal
Elastatinal (0.5 mg vial)
Epoxomicin (0.2 mg vial)
Foroxymithine
Foroxymithine (0.5 mg vial)
H-Dab-Pip
KYT-1 (1 mg vial)
KYT-36 (1 mg vial)
6

Leuhistin
Leuhistin (0.5 mg vial)
Leupeptin
Leupeptin (0.5 mg vial)
Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Tyr (0.5 mg vial)
L-685,458 (1 mg vial)
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe (1 mg vial)
N-(4-Biphenylacetyl)-Cys(Me)-D-Arg-Phe-N-Phenylethylamide
Pepstatin A (Purity Higher than 90% by HPLC)
Pepstatin A (0.5 mg vial) (Purity Higher than 90% by HPLC)
Phebestin (5 mg vial)
Phosphoramidon
Phosphoramidon (0.5 mg vial)
SIMP-2

SUAM-14746 (5 mg vial)
TAPI-0
TAPI-1
TAPI-2
Ubenimex (Bestatin)
Ubiquitin Aldehyde, Semisynthetic Product (50 碌g vial)
Z-Asp-CH2-DCB (5 mg vial)
Z-Glu-Lys(Biotinyl)-Asp-CH2-DMB (1 mg vial)
Z-Ile-Glu(OtBu)-Ala-Leu-H (aldehyde) (5 mg vial)
Z-Leu-Leu-H (aldehyde) (5 mg vial)
Z-Leu-Leu-Leu-H (aldehyde) (5 mg vial)
Z-Leu-Leu-Nva-H (aldehyde) (5 mg vial)
Z-Val-Ala-Asp(OMe)-CH2F (1 mg vial)
GalardinTM
SNE-3230-v
上海惠诚生物为广大科研用户提供科学仪器,试剂耗材等专业科研产品服务。
代理产品品牌有:Nu-chek、LKT、AccuStandard、APSC、MPBio、Sigma-Aldrich、NIST,Reagecon、Megazyme,LGC、Ultra,日本和光(WAKO)、Shodex,Dr.E、PSS ,Matreya,CaroteNature瑞典Larodan产品,Chromadex等。提供美国药典USP 、欧洲药典标 EDQM、加拿大TRC标准物质等

TEL: 137888991907   E-mail:TEL NO @163.COM
专业提供1mg  ,5mg 

Cpp-AAF-pAb 1mg/2190元,5mg
N-[(RS)-1-Carboxy-3-phenyl-propyl]-Ala-Ala-Phe-4-Abz-OH          
Specific inhibitor of thimet                                                             
M.Orlowski et al., Biochemistry, 27, 597 (1988)
D.T.O.Martins et al., Br. J. Pharmacol., 103, 1851 (1991)
C.H.Williams et al., Biochem. J., 294, 681 (1993)
R.Yamin et al., J. Biol. Chem., 274, 18777 (1999)
IDE Inhibitor 6bK  1 mg / 7992元,5mg
(Fumaryl-Lys-Cha-D-Bpa)-Lys-NH2 (M.W. 757.94) C41H55N7O7 Inhibitor of IDE or Insulin-Degrading Enzyme; Blocks Insulin Breakdown
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