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异甘草素 soliquiritigenin, natural / 961-29-5 生化实验用  

2014-09-22 14:29:36|  分类: 生物化学试剂 |  标签: |举报 |字号 订阅

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异甘草素 soliquiritigenin, natural / 961-29-5 生化实验用 - Solomon - 标准品生化试剂毒素酶试剂盒
Cat. Number
I7559
Chemical Name
异甘草素 Isoliquiritigenin
CAS Number
961-29-5
Mol. Formula
C15H12O4
Mol. Weight
256.25
Qty 1
5mg
Qty 2
25mg
Application Notes
≧98%(HPLC)
Synonym
Isoliquiritigenin, natural;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one ;4,2′,4′-Trihydroxychalcone
Storage condition
+4°C
References

Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylase (HDAC), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of cancer cells.

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相关引用文献:
Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.
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