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Jackson二抗授权|蛋白|细胞因子

西宝生物科研试剂团队服务糖,寡糖,多糖及检测服务和原料供应。Jackson二抗

 
 
 

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R&D Systems公司细胞生物学,提供优质的蛋白质,抗体,ELISA试剂盒,实验室试剂,细胞因子.包括Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics. Jackson二抗中国授权代理

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共轭亚油酸系列生化科研实验用  

2014-09-05 15:42:27|  分类: 生物化学试剂 |  标签: |举报 |字号 订阅

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Linoleic acid 
is an essential fatty  acid (18:2 ω6)   of which  several naturally  o ccurring  conjugated derivatives  havebeen identified. These derivatives, called “conjugated linoleic acid” or CLA can have the two double bonds mainly inthe 9 and 11 or in the 10 and 12 positions,  resulting in eight possible geometric  isomers. CLA occurs in meat (41)and dairy products (42, 43). In both cases, the 9(Z),11(E)-isomer is predomi nant and is thought to be the biologicall yactive form. CLA assimilated through the diet of animals is found in the intestinal musosa, liver and adipose tissue(44). See also review article by Parodi (43). CLA has several biological properties. It’s anti-carcinogenic activity hasbeen demonstrated by its ability to inhi bit chemically induced tumor formation in animal models of carcinogenesis(41,45-47). The addition of CLA to culture medium suppresses the  in vitro growth of human melanoma, colorectaland breast cancer cells (48). CLA also  exhibits anti-atherogenic activity. Addi tion of CLA to a controlled atherogenicdiet significantly reduced the developm ent of atherosclerosis in hamsters and rabbits ( 49,50). Animals fed a dietcontaining CLA also had lower levels of low-density-lipoprot ein (LDL) cholesterol. CLA may be involved in regulatingfat and protein metabolism (51,52). Se veral species of animals fed CLA-supplemented diets s howed improved feedefficiency. Lean body mass increased while body fat was reduced.  This seems to be due, mainly or exclusively, to the10(E),12(Z)-isomer  . CLA competes with linoleate for   6 desaturase (53). Dietary CLA normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa  rat (54) via activation of PPARγ, a resultwhich bears on the possible ameliorization or prevention of NIDDM. The 11(Z),13(E)-isomer hasbeen shown to be concentrated in  the heart and in mitochondria. 
Most studies to date have utilized a mi xture of CLA isomers containing less than 30% of the presumed active9(Z),11(E)-isomer (55,56). In addition to the 9,11- and 10,12-isomers, 8,10- and 11,13-isomers have recently beenidentified in the widely used mixture ( 56,57). Matreya offers a highly pure CLA which is 98+% the active 9,11-“cis,trans” isomer. The corresponding “trans,trans” and “cis,cis” isomers are also available. In addition, we now offer  thepure 10(E),12(Z)-isomer, which has been widely sought for comparison studies.  

9(Z),11(E)-Octadecadienoic acid     25mg ,1g

9- cis, 11- trans CLA     C18H32O2
   CAS#:  2540-56-9
Source:  synthetic   Mol. Wt.:  280   Purity:  98+% by TLC, GC   Appearance:  liquid
Solubility:  chloroform, ethanol, hexane, methanol, DMSO

Methyl 9(Z), 11(E)-octadecadienoate  25mg
Methyl ester of CLA (9-cis, 11- trans)     C19H34O2
ource:  synthetic   Mol. Wt.:  294   Purity:  98+% by TLC, GC   Appearance:  liquid 
Solubility:  chloroform, ethanol, hexane, methanol
 
9(E),11(E)-Octadecadienoic acid   25mg 
9- trans, 11- trans CLA     C18H32O2
   CAS#:  544-71-8
Source:  synthetic   Mol. Wt.:  280   Melting Point (°C):   55-57   Purity:  98+% by TLC,
GC   Appearance:  solid   Solubility:  chloroform, ethanol, hexane, methanol  

Methyl 9(E),11(E)-octadecadienoate   25mg 
Methyl ester of CLA (9-trans, 11- trans)     C19H34O2
Source:  synthetic   Mol. Wt.:  294   Purity:  98+% by TLC, GC   Appearance:  liquid 
Solubility:  chloroform, ethanol, hexane, methanol 

9(Z),11(Z)-Octadecadienoic acid   25mg 
9- cis, 11- cis CLA     C18H32O2
   CAS#:  544-40-7 
Source:  synthetic   Mol. Wt.:  280   Melting Point (°C):   40-42   Purity:  96+% by TLC, GC  
Appearance:  solid   Solubility:  chloroform, ethanol, methanol, ethyl ether 

Methyl 9(Z), 11(Z)-octadecadienoate   25mg
Methyl ester of CLA (9-cis, 11- cis)     C19H34O2
Source:  synthetic   Mol. Wt.:  294   Purity:  96+% by TLC, GC   Appearance:  liquid 
Solubility:  chloroform, ethanol, hexane, methanol

10(E),12(Z)-Octadecadienoic acid     25mg ,1g

10-trans, 12- cis CLA     C18H32O2
   CAS#:  2420-44-2 
Source:  synthetic   Mol. Wt.:  280   Purity:  98+% by TLC, GC   Appearance:  liquid 
Solubility:  chloroform, ethanol, hexane, methanol

Methyl 10(E), 12(Z)-octadecadienoate   25mg

Methyl ester of CLA (10-trans, 12- cis)     C19H34O2
Source:  synthetic   Mol. Wt.:  294   Purity:  98+% by TLC, GC   Appearance:  liquid

11(Z), 13(E)-Octadecadienoic acid   25mg
11-cis, 13- trans CLA     C18H32O2
Source:  synthetic   Mol. Wt.:  280   Purity:  77% cis, trans; 2 % cis, cis;  6% trans, trans
by TLC, GC   Appearance:  liquid   Solubility:  chloroform, ethanol, hexane, methanol 

9(Z),11(E)-Octadecadienoic acid    1g,10g
9- cis, 11- trans CLA     C18H32O2
   CAS#:  2540-56-9
 Source:  synthetic   Mol. Wt.:  280   Purity:  74% 9(Z),11(E); 17%(Z),(Z); 1%(E),(E) by
TLC, GC  Appearance:  liquid   Solubility:  ethanol, ethyl ether, hexane  

Methyl 9(Z),11(E)-octadecadienoate      25 mg
Methyl ester of CLA (9-cis, 11- trans)     C19H34O2
Source:  synthetic   Mol. Wt.:  294 
Purity: 74% 9(Z),11(E); 17%(Z),(Z); 1% (E),(E) by TLC, GC 
Appearance:  liquid   Solubility:  chloroform, ethyl ether, hexane
TEL: 137888991907   E-mail:TEL NO @163.COM
上海惠诚生物为广大科研用户提供科学仪器,试剂耗材等专业科研产品服务。

代理产品品牌有:Nu-chek、LKT、AccuStandard、APSC、MPBio、Sigma-Aldrich、NIST,Reagecon、Megazyme,LGC、Ultra,日本和光(WAKO)、Shodex,Dr.E、PSS ,Matreya,CaroteNature瑞典Larodan产品,Chromadex等。提供美国药典USP 、欧洲药典标 EDQM、加拿大TRC标准物质等
专业提供中草药单体标准品,HPLC 98%以上,20mg/瓶,及500mg、1g定制询价.
Other CLA Products and Derivatives
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphorylcholine           25 mg/ml, 1ml 
C44H84NO8P 
Source:  synthetic   Mol. Wt.:  786   Purity:  98+% by TLC  Appearance:  liquid 
Solvent:  chloroform   Solubility:  chloroform, ethanol  

1-Stearoyl-2-[9(Z),11(E)-octadecadienoyl]-sn-glycero-3-phosphorylcholine     25 mg/ml, 1ml 
C44H84NO8P 
Source:  synthetic   Mol. Wt.:  786   Purity:  98+% by TLC  Appearance:  liquid

1-Stearoyl-2-[10(E),12(Z)-octadecadienoyl]-sn-glycero-3-phosphorylcholine     25 mg/ml, 1ml 
C44H84NO8P 
Source:  synthetic   Mol. Wt.:  786   Purity:  98+% by TLC  Appearance:  liquid 
Solvent:  chloroform   Solubility:  chloroform, ethanol
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